Figure 2.

Changes in daily proteinuria outcomes in patients treated with immunosuppressants. Changes in daily proteinuria are expressed as the ratio of means (response ratio) between measurements from the last time point reported and baseline. Study arms with the same treatment within 1 study were included if they corresponded to different patient populations. In Agrawal et al⁷ the patients were tacrolimus responsive (first arm in the figure) and tacrolimus resistant (second arm in the figure); in Mahmoud et al¹⁰ the patients had SRNS (first arm in the figure, arm 2 in Table 1) and SDNS (second arm in the figure, arm 1 in Table 1). The summary effect of all studies, regardless of the type of immunosuppressant therapy, is highlighted in bold. Abbreviations: ACEi, angiotensin-converting enzyme inhibitors; AH, antihypertensives; AP, antiplatelets; ARB, angiotensin receptor blockers; AsA, acetylsalicylate; CCB, calcium channel blockers; chl, chloramphenicol; CI, confidence interval; CsA, cyclosporine A; CYC, cyclophosphamide; MMF, mycophenolate mofetil; Pred, prednisone; ROM, ratio of means; RTX, rituximab; SD, standard deviation; SDNS, steroid-dependent nephrotic syndrome; SRNS, steroid-resistant nephrotic syndrome; Tac, tacrolimus.