Changes in CrCl in patients treated with immunosuppressants. Changes in CrCl are expressed as the MD between measurements at the last time point and baseline. The summary effect of all studies, regardless of the type of immunosuppressant therapy, is highlighted in bold. Abbreviations: ACEi, angiotensin-converting enzyme inhibitors; AH, antihypertensives; ARB, angiotensin receptor blockers; CI, confidence interval; CrCl, creatinine clearance; CsA, cyclosporine A; MD, mean difference; Pred, prednisone; SD, standard deviation; Tac, tacrolimus.