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. 2022 Aug 10;13:920261. doi: 10.3389/fendo.2022.920261

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Copyright © 2022 Chan, Wong and Pearson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circadian rhythms and their disruption: Topics to be discussed in this review. Circadian rhythms, influenced by light/dark cycles and diet and time of food intake, control many pancreas functions. Disruption to these circadian influences (altered light exposure, shift work/jet lag, genetic mutations) can lead to weight gain and dysregulated blood glucose homeostasis increasing the risk of developing obesity and T2DM. For information related to these factors altering the circadian rhythms please see the specific sections mentioned above within the review. Section 3: Circadian rhythms in the pancreas, Section 4: Molecular circadian rhythms in the pancreas and Section 5: Modulation of circadian rhythm.