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Modulation of host circadian rhythms. Circadian rhythms can be modulated through a number of interventions, including changes to the central clock via changes in the light/dark cycle or sleep/wake cycle, as well as changes to peripheral clocks e.g. food restriction. Disruption to the central clock can lead to disconnection from the peripheral clocks and vice versa. These changes to the circadian rhythm are often experienced by those with jet lag or in overnight shift workers. .
