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. 2022 Aug 10;13:968288. doi: 10.3389/fneur.2022.968288

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Copyright © 2022 Nordström, Forsse, Jakobsen, Mölström, Nielsen, Toft and Ungerstedt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean arterial blood pressure (MAP) and intracerebral levels of glucose and lactate/pyruvate (LP) ratio during 240 min before, during and after a 90 min period (A) and a 60 min period (B) of hemorrhagic shock. In both panels MAP decreased to 40 mmHg. Panel A illustrates the biochemical pattern during severe cerebral ischemia. Panel B illustrates a pattern when intracerebral glucose an LP ratio are relatively unaffected during a similar but shorter decrease in MAP. Data from (94, 95) are shown as Mean ± SEM.