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. 2022 Aug 10;13:941210. doi: 10.3389/fendo.2022.941210

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Copyright © 2022 Zhang, Gao, Liu, Qin, Ye, Lou, Wang, Zhang, Chen, Chen, Yu, Zhuo, Xu and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–D) Immunohistochemistry staining of Ki67 in available paired primary tumors and metastases, showing G1 increase to G2, G1 increase to G3, G2 increase to G3, and G2 decrease to G1, respectively. Magnification: 400×. (E) Association among clinicopathological characteristics, Ki67 index variation and grade changes. (a) Metachronous metastases showed higher Ki67 index variation than synchronous metastases. (b, c) Patients with AJCC 8^th stage I/II showed higher frequency of grade increase, and G1/G2 increase to G3 than patients with AJCC 8^th stage III/IV.