Table 2. Ki67 index variation and grade changes in metastases compared to primary tumors in PanNETs.

Ki67 index variation	Study cohort (n=103)	Resection cohort (n=91)	Biopsy cohort (n=12)
Patient number (%)	50 (48.5)	43 (47.3)	7 (58.3)
Delta Ki67 index, median (range)	0 (-14 to +29)	0 (-14 to +29)	0.5 (-5 to +27)
Tumor grade
Stable, n (%)	79 (76.7)	70 (76.9)	9 (75.0)
Grade increase, n (%)	18 (17.5)	15 (16.5)	3 (25.0)
G1 increase to G2	7 (6.8)	6 (6.6)	1 (8.3)
G1 increase to G3	4 (3.9)	4 (4.4)	0 (0)
G2 increase to G3	7 (6.8)	5 (5.5)	2 (16.7)
Grade decrease, n (%)
G2 decrease to G1	6 (5.8)	6 (6.6)	0 (0)