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. 2022 Aug 10;13:960279. doi: 10.3389/fendo.2022.960279

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Copyright © 2022 Koorneef, van der Meulen, Kooijman, Sánchez-López, Scheerstra, Voorhoeve, Ramesh, Rensen, Giera, Kroon and Meijer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Corticosterone adds to dexamethasone-induced gene expression. Mice received a high-fat diet mixed with dexamethasone (DEX) or vehicle (VEH) and were subcutaneously implanted with low-dose (5 mg) corticosterone (CORT) or vehicle pellets for 3.5 weeks. (A–D) DEX increased expression of GR target genes Fkbp5, Gilz and Mt2a stronger than CORT in interscapular brown adipose tissue (iBAT), subcutaneous white adipose tissue (sWAT), gonadal white adipose tissue (gWAT) and liver, while the induction after DEX + CORT was highest. (E) In the hippocampus, DEX decreased Fkbp5 expression and did not regulate Gilz and Mt2a expression. DEX + CORT normalized Fkbp5, and induced Gilz, Mt2a and Jdp2 expression. Statistical significance was calculated using 2-way ANOVA analysis. Depicted below the graphs are the P-values of the ANOVA tests for either CORT (C), DEX (D) or the interaction between CORT and DEX (I). *P < 0.05, ** P < 0.01, ***P < 0.001. 'ns' means 'not significant'.