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. 2022 Aug 10;13:960279. doi: 10.3389/fendo.2022.960279

Figure 7.

Figure 7

Aldosterone add-on treatment did not influence the metabolic effects of dexamethasone. Mice received a high-fat diet mixed with dexamethasone (DEX) or vehicle (VEH) and were subcutaneously implanted with aldosterone (ALDO) or vehicle pellets for 10 days. (A) ALDO did not affect corticosterone levels at AM (ZT1) and PM (ZT11) of the light phase, while CORT levels were not detected (n.d.) after DEX and DEX + ALDO treatment. (B–D) DEX + ALDO did not influence the DEX-induced reduction of body weight, fat mass and lean mass. (E, F) 6 h-fasted plasma glucose or insulin levels were unaffected by ALDO and DEX + ALDO. (G) ALDO, DEX and DEX + ALDO reduced gonadal white adipose tissue (gWAT) weight Statistical significance was calculated using 3-way ANOVA in (A-D) and 2-way ANOVA analysis in (E–G). Depicted below the graphs are the P-values of the ANOVA tests for either ALDO (A), DEX (D), or the interaction between ALDO and DEX (I). *P < 0.05, ** P < 0.01, ***P < 0.001. 'ns' means 'not significant'.