Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 10;13:960279. doi: 10.3389/fendo.2022.960279

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Koorneef, van der Meulen, Kooijman, Sánchez-López, Scheerstra, Voorhoeve, Ramesh, Rensen, Giera, Kroon and Meijer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Eplerenone prevents additional induction by corticosterone add-on on target gene expression. Mice received a high-fat diet mixed with vehicle (VEH), dexamethasone (DEX) with or without eplerenone (Ep) and were subcutaneously implanted with corticosterone (CORT) or vehicle pellets for 3.5 weeks. (A–C) Ep reduced the induction of Mt2a and Fkbp5 expression by DEX and DEX + CORT in interscapular brown adipose tissue (iBAT), gonadal white adipose tissue (gWAT) and liver. (D) Fkbp5, Mt2a and Jdp2 expression was increased by DEX + CORT, and more so by DEX + CORT + Ep in the hippocampus. The vehicle group was excluded from statistical analyses. Statistical significance was calculated using 2-way ANOVA analysis. Depicted below the graphs are the P-values of the ANOVA tests for either CORT (C), Ep (E) or the interaction between CORT and Ep (I). *P < 0.05, ** P < 0.01, ***P < 0.001. 'ns' means 'not significant'.