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. 2022 Aug 10;13:926650. doi: 10.3389/fimmu.2022.926650

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Copyright © 2022 Wenzlau, DiLisio, Barbour, Dang, Hohenstein, Nakayama, Delong, Baker and Haskins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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I-A^g7 binding pocket 9 and optimal limits of the 6.3HIP antigen. (A) Determination of 6.3HIP residue occupying p9 of I-A^g7. IFN-γ ELISA assays of T cell clones BDC-6.3 and PD12-4.4 stimulated with 6.3HIP_1-14 antigen compared to 6.3HIP substituted with 12D>R or 10D>R. (B) Response to C-terminal truncations of the 6.3HIP. IFN-γ production by BDC-6.3 and PD12-4.4 in response antigens 6.3HIP, 6.3HIP_1-11 and 6.3HIP_1-10. (C) Limits of the 6.3HIP epitope N-terminus. IFN-γ production by BDC-6.3 and PD12-4.4 in response to peptides 6.3HIP. 6.3HIP_-1-14, and 6.3HIP_2-14. Blue = B:9-23 sequence, red italics = ProSAAS sequence. Representative data from 4 experiments (A), 6 experiments (B), and 4 experiments (C) shown as ng/ml IFN-γ.