Table 1.
Features of insulin-responsive T cell clones.
| Clone | TCR α | TCR ß | Insulin/B:9-23 | DT NOD | DT NOD.scid | DT NOD/Haskins | CDR3 α | CDR3 ß |
|---|---|---|---|---|---|---|---|---|
| BDC-6.3 | TRAV5D-4 | TRAB5 | + | N/A | N/A | 5/7 13-23 days |
CAASAVGSGGSNYKLTF | CASSQEGGGNEQYF |
| PD12-4.4 | TRAV5D-4 | TRAB5 | + | 7/9 9-24 days |
½ 16 days |
4/6 9-24 days |
CAASASGGSNYKLTF | CASSQDTNTGQLYF |
Listed are TCR Vα, Vβ and CDR3 α and β designations and T cell stimulation scores (+ or -) for responses to insulin and B-chain peptide B:9-23 for the set of two T cell clones. Diabetogenicity of each clone was assessed by injecting 6-18 day-old indicated recipient mice with 1 X 107 T cells and monitoring for incidence of diabetes 3-4 wks post transfer. Disease transfer (DT) numbers represent the number of diabetic mice/total number of mice injected.