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. 2022 Aug 10;13:967953. doi: 10.3389/fimmu.2022.967953

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Copyright © 2022 Rosenstein, Rasch, Axelsson, Novakova, Blennow, Zetterberg and Lycke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of baseline cNFL and ITMS to predict EDA-3, EDSS≥3, and EDSS≥6. Forest plot with adjusted hazard ratios for risks of achieving EDA-3 status within 24 months, EDSS≥3, and EDSS≥6, stratified by combinatory possibilities of cNFL and ITMS. cNFL, cerebrospinal fluid neurofilament light; ITMS, intrathecal IgM synthesis; EDA, Evidence of Disease Activity; IgM, immunoglobulin M; IF, intrathecal fraction; OCMB, oligoclonal IgM band; EDSS, expanded disability status scale; Ig, immunoglobulin; CI, confidence interval.