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. 2022 Aug 10;13:967953. doi: 10.3389/fimmu.2022.967953

Table 3.

Combined cNFL and IgM-index.

Cox proportional hazards
aHR 95% CI p value
EDA-3

  • cNFL-/IgMindex-

 Ref. – –

  • cNFL+/IgMindex-

 1.4 0.7-2.8 0.3

  • cNFL-/IgMindex+

 2.2 1.2-4.1 0.01

  • cNFL+/IgMindex+

 3.3 1.8-6.1 <0.001

  • cNFL-/IgMIF>0%-

 Ref. – -

  • cNFL+/IgMIF>0%-

 1.4 0.8-2.3 0.2

  • cNFL-/IgMIF>0%+

 3.6 2.2-6 <0.001

  • cNFL+/IgMIF>0%+

 4.9 3.1-7.8 <0.001

  • cNFL-/OCMB-

 Ref. – –

  • cNFL+/OCMB-

 2.1 1.2-3.6 0.008

  • cNFL-/OCMB+

 1.8 0.9-3.3 0.06

  • cNFL+/OCMB+

 2.8 1.6-4.7 <0.001
EDSS≥3

  • cNFL-/IgMindex-

 Ref. – –

  • cNFL+/IgMindex-

 2.3 1.2-4.3 0.01

  • cNFL-/IgMindex+

 1.8 0.9-3.3 0.06

  • cNFL+/IgMindex+

 4.6 2.6-8.2 <0.001

  • cNFL-/IgMIF>0%-

 Ref. – –

  • cNFL+/IgMIF>0%-

 1.7 1.04-2.8 0.035

  • cNFL-/IgMIF>0%+

 0.7 0.4-1.5 0.4

  • cNFL+/IgMIF>0%+

 2 1.5-5.1 <0.001

  • cNFL-/OCMB-

 Ref. – –

  • cNFL+/OCMB-

 1.7 0.9-3.1 0.12

  • cNFL-/OCMB+

 1.2 0.6-2.4 0.7

  • cNFL+/OCMB+

 3.3 1.7-6.4 <0.001
EDSS≥6

  • cNFL-/IgMindex-

 Ref. – –

  • cNFL+/IgMindex-

 5.7 1.5-22.7 0.01

  • cNFL-/IgMindex+

 3.7 1-13.8 0.05

  • cNFL+/IgMindex+

 8.2 2.3-30 <0.001

  • cNFL-/IgMIF>0%-

 Ref. – –

  • cNFL+/IgMIF>0%-

 2.4 0.9-6.2 0.06

  • cNFL-/IgMIF>0%+

 0.8 0.2-2.9 0.8

  • cNFL+/IgMIF>0%+

 3.4 1.05-10.9 0.04

  • cNFL-/OCMB-

 Ref. – –

  • cNFL+/OCMB-

 1.97 0.6-6.5 0.26

  • cNFL-/OCMB+

 2 0.53-7.6 0.31

  • cNFL+/OCMB+

 7.4 2.3-24.4 <0.001

aHR, adjusted hazard ratio; CI, confidence interval; EDA, Evidence of Disease Activity; cNFL, cerebrospinal fluid neurofilament light; Ig, immunoglobulin; IF, intrathecal fraction; EDSS, expanded disability status scale; OCMB, oligoclonal IgM bands. Multivariable analysis assessing the additive predictive value of cNFL and IgM-index regarding EDA-3 status at 24 months after the first relapse, EDSS≥3, and EDSS≥6. Bold p values indicate statistical significance (p<0.05).