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. 2022 Aug 10;9:919748. doi: 10.3389/fmed.2022.919748

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Copyright © 2022 Boyle, Prideaux, Hillman, Wang and Firestein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNAseq fold change comparison of gene expression using different disaggregation protocols. (A–D) Relative changes in each gene for the 3 protocols compared to intact are shown for the top 50% of expressed genes. Genes that are represented below the line are induced more in Lib compared with Lib+Flavo or SubA. (E,F) Distribution of gene expression changes in each protocol for RA and OA. Histograms are colored by disaggregation protocol. A log2 scale is used on the x-axis, so “zero” represents identical expression compared with intact. Points to the right represent induced genes.