Table 2.

Differential pathways lost or enriched by each disaggregation protocol relative to intact tissue.

Pathway description	Intact tissue	Sub A	Liberase + Flavo	Liberase
Interleukin-4 and Interleukin-13 signaling	6.4E−08	2.5E−06
Assembly of collagen fibrils and other multimeric structures	9.8E−05	6.0E−03
Interleukin-10 signaling	3.4E−08	2.7E−05	1.4E−03
Signaling by Interleukins	1.1E−06	3.9E−04	2.4E−03
Signaling by NOTCH3	3.5E−03	1.5E−03	9.7E−03
Extracellular matrix organization	6.4E−08	5.6E−10	3.8E−06	3.9E−06
Chemokine receptors bind chemokines	1.5E−06	2.7E−05	1.0E−04	3.3E−06
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	6.4E−08	1.2E−04	2.4E−05	5.5E−08
Integrin cell surface interactions	4.8E−07	1.3E−04	4.3E−05	3.9E−05
GPCR ligand binding	1.2E−03	4.5E−04	3.9E−04	1.3E−04
Class A/1 (Rhodopsin-like receptors)	5.5E−05	7.9E−04	3.0E−05	1.7E−05
Peptide ligand-binding receptors	1.3E−04	7.2E−03	8.0E−06	3.1E−05
G alpha (i) signaling events	1.4E−03	4.5E−03	3.0E−03	1.7E−04
Binding and Uptake of Ligands by Scavenger Receptors	2.8E−05
Collagen degradation	2.8E−05
Degradation of the extracellular matrix	5.7E−05
Collagen chain trimerization	2.0E−03
RAF-independent MAPK1/3 activation	2.1E−03
Collagen formation	3.0E−03
NOTCH3 Intracellular Domain Regulates Transcription	3.1E−03
Interleukin-6 signaling	8.4E−03
Scavenging of heme from plasma		9.1E−03		1.4E−03
Elastic fiber formation		2.4E−07
Molecules associated with elastic fibers		3.1E−04
Signaling by NOTCH1		4.5E−03
Erythrocytes take up carbon dioxide and release oxygen			3.0E−03
O2/CO2 exchange in erythrocytes			3.0E−03
Syndecan interactions			4.7E−03
Triglyceride metabolism				8.6E−03