Table 3.
Meta-analysis results of the TPOAb-negative subgroup.
| Outcome | Included studies | Number of studies | Number of patients | RR or OR (95%CI) | P-value | I2 | Model |
|---|---|---|---|---|---|---|---|
| Preterm delivery | all RCTs | 4 | 1480 | 0.49 (0.34, 0.69) | < 0.001 | 0% | Fix |
| RCTs with low and moderate risk of bias | 1 | 146 | 0.37 (0.14, 0.95) | 0.040 | 0% | Fix | |
| all cohort studies | 4 | 2993 | 0.77 (0.30, 1.96) | 0.580 | 85% | Random | |
| cohort studies with low and moderate risk of bias | 1 | 93 | 2.70 (0.47, 15.55) | 0.270 | 0% | Fix | |
| Miscarriage | all RCTs | 3 | 1334 | 0.43 (0.32, 0.59) | < 0.001 | 6% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 2 | 2219 | 0.97 (0.59, 1.59) | 0.900 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Gestational hypertension | all RCTs | 3 | 1344 | 0.49 (0.34, 0.72) | < 0.001 | 0% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 3 | 2900 | 0.84 (0.62, 1.13) | 0.250 | 2% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Gestational diabetes | all RCTs | 2 | 194 | 0.38 (0.15, 0.96) | 0.040 | 0% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 2 | 1501 | 0.46 (0.26, 0.83) | 0.010 | 55% | Random | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Postpartum hemorrhage | all RCTs | 0 | 0 | NA | NA | NA | NA |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 1 | 93 | 0.63 (0.05, 7.14) | 0.710 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 1 | 93 | 0.63 (0.05, 7.14) | 0.710 | 0% | Fix | |
| Placental abruption | all RCTs | 1 | 134 | 0.33 (0.01, 8.04) | 0.500 | 0% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 3 | 2900 | 1.23 (0.70, 2.17) | 0.470 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Fetal growth restriction | all RCTs | 1 | 134 | 0.50 (0.16, 1.58) | 0.240 | 0% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 2 | 2219 | 0.99 (0.72, 1.37) | 0.970 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Fetal distress | all RCTs | 1 | 134 | 0.86 (0.30, 2.42) | 0.770 | 0% | Fix |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 3 | 2900 | 0.66 (0.44, 0.99) | 0.040 | 48% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Premature rupture of membranes | all RCTs | 0 | 0 | NA | NA | NA | NA |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 1 | 681 | 0.80 (0.47, 1.38) | 0.420 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| Low birth weight | all RCTs | 2 | 1274 | 0.45 (0.19, 1.08) | 0.070 | 54% | Random |
| RCTs with low and moderate risk of bias | 0 | 0 | NA | NA | NA | NA | |
| all cohort studies | 4 | 2993 | 0.99 (0.72, 1.37) | 0.970 | 0% | Fix | |
| cohort studies with low and moderate risk of bias | 1 | 93 | 3.89 (0.15, 97.99) | 0.410 | 0% | Fix |
TPOAb, thyroid peroxidase antibody; RCTs, randomized controlled trials; RR, risk ratio; OR, odds ratio; CI, confidence interval; I2, statistical heterogeneity; NA, not applicable since no studies were included; According to the pre-defined rules, the meta-analysis results with gray background were used to draw conclusions for each outcome.