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. 2022 Aug 10;12:947604. doi: 10.3389/fonc.2022.947604

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Copyright © 2022 Bhagat, Shrestha, Jeyabal, Peng, Watowich and Kleinerman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of neutrophil elastase knockout (NE^-/-) on heart function and cardiac vessel morphology 12 weeks after therapy. (A) Ejection Fraction (EF) and fractional shortening (FS) were quantified by echocardiography and followed for 12 weeks after treatment with control phosphate-buffered saline (PBS) or doxorubicin (DOX) in wild-type and NE^-/- mice; (B) Representative images of cardiac NG2⁺ and CD31⁺ vessels 12 weeks after therapy and frequency (%) vessels with >100µm/hpf. Data are presented as mean ± SEM, n = 5 each, *p < 0.05, one-way ANOVA analysis with Tukey comparison was used to compare the groups.