Figure 1.

Flow chart of the work on screening and identifying a key gene associated with biochemical recurrence of prostate cancer and validating some potential biological functions. PCa, prostate cancer; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DO, Disease Ontology; DEGs, differentially expressed genes; Lasso, least absolute shrinkage and selection operator; SVM-RFE, support vector machine with recursive feature elimination; PPI, protein-protein interaction; MCODE, molecular complex detection; GSEA, gene set enrichment analysis; ROC, receiver operating characteristic; TCGA, The Cancer Genome ATLAS; PRAD, prostate adenocarcinoma; LTBP2, latent transforming growth factor β-binding protein 2; ceRNA, competitive endogenous RNA; TME, tumor microenvironment.