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. 2022 Jul 8;24(3):563. doi: 10.3892/etm.2022.11500

Figure 2.

Figure 2

Screening and identification of LTBP2 as a key DEG associated with BCR of PCa. (A) Lasso Cox regression algorithm was applied to screen DEGs associated with BCR of PCa in GEO-merged datasets. (B) SVM-RFE algorithm was performed to identify DEGs associated with BCR of PCa in GEO-merged datasets. (C) Venn diagram showing the overlap of 19 BCR-based DEGs between the two different algorithms. (D) PPI analysis of BCR-related DEGs in PCa using STRING database. (E) The STRING outcomes were uploaded to Cytoscape software to identify hub genes using MCODE algorithm in the PPI network. (F) Venn diagram revealed that LTBP2 was the only BCR-associated hub gene. LTBP2, latent transforming growth factor β-binding protein 2; DEG, differentially expressed gene; BCR, biochemical recurrence; PCa, prostate cancer; Lasso, least absolute shrinkage and selection operator; GEO, Gene Expression Omnibus; SVM-RFE, support vector machine with recursive feature elimination; PPI, protein-protein interaction; STRING, The Search Tool for Retrieving Interacting Genes; MCODE, molecular complex detection.