Table 8.
Associations between DINP, DBP, DIBP, BBP, and DEP exposure and time to pregnancy
| Reference; Study confidence; N | Mean exposure (IQR) (ng/mL) | Fecundability OR (95% CI) | Fecundability OR unit change |
|---|---|---|---|
| DINP | |||
| Jukic et al. (2016) ; Hish; 221 | MCiOP 3.3 (2.3–5.2) | Q2: 0.93 (0.66, 1.32) Q3: 0.96 (0.68, 1.35) | T2 and T3 vs. T1 |
| DBP | |||
| Buck Louis et al. (2014); Medium; 501 | 10 | 0.93 (0.77, 1.12) | 1 SD change (log transformed) |
| Jukic et al. (2016); High; 221 | 80 (49–127) | Q2: 0.90 (0.63, 1.27) Q3: 0.96 (0.68, 1.35) | T2 and T3 vs. T1 |
| Thomsen et al. (2017); Medium; 229 | 272 (range 10–2,292) | 1.03 (0.76,1.39) | 1 unit increase (ln transformed) |
| DIBP | |||
| Jukic et al. (2016) ; Hieh; 221 | 3.1 (1.9–5.0) | Q2: 1.16 (0.81, 1.65) Q3: 1.11 (0.77, 1.61) | Tertile vs. T1 |
| Buck Louis et al. (2014) ; Medium; 501 | 5.1 | 0.95 (0.78, 1.14) | 1 SD change (log transformed) |
| BBP | |||
| Buck Louis et al. (2014) ; Medium; 501 | 5 | 0.94 (0.78, 1.13) | 1 SD change (log transformed) |
| Thomsen et al. (2017) ; Medium; 229 | 22 (range 1.0–203) | 0.88 (0.64,1.19) | 1 unit increase (ln transformed) |
| Jukic et al. (2016) ; High; 221 | 40 (25–69) | Q2: 0.76 (0.53, 1.10) Q3: 1.01 (0.73, 1.40) | T2 and T3 vs. T1 |
| DEP | |||
| Thomsen et al. (2017) ; Medium; 229 | 379 (range 16–12,357) | 0.79 (0.63,0.99)* | 1 unit increase (ln transformed) |
| Buck Louis et al. (2014) ; Medium; 501 | 94 | 0.97 (0.84, 1.12) | 1 SD change (log transformed) |
| Jukic et al. (2016) ; Hieh; 221 | 134 (72–296) | Q2: 1.00 (0.71, 1.42) Q3: 0.98 (0.68, 1.40) | T2 and T3 vs. T1 |
Fecundability OR < 1 indicates increased time to pregnancy.
*
p < 0.05, results that support an association are shaded. Q=quartile; T = tertile.