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. 2022 Aug 23;23:611. doi: 10.1186/s12864-022-08806-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The genomic characteristic of m⁶A-circRNAs in OSCC. A, B The exons quantity of up-regulated and down-regulated m⁶A-modified circRNAs were counted in differentially expressed m⁶A-modified circRNAs, including up-regulated (100 m⁶A-circRNAs) and down-regulated (90 m⁶A-circRNAs). C, D The length (spliced length, not genomic length) was counted by stages count (~ 100 bp). E, F Metagene profiles of enrichment of m⁶A modification sites on mRNA and circRNA of gene locus across RNA transcriptome. 5’-untranslated regions (5’-UTR), coding sequences (CDS), 3’-untranslated regions (3’-UTR)