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. 2022 Aug 23;23:611. doi: 10.1186/s12864-022-08806-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The association of m⁶A-circRNAs and m⁶A-mRNA in OSCC. A Schematic diagram illustrated the biogenesis of m⁶A-circRNAs and m⁶A-mRNA in OSCC cells. The m⁶A modification was installed by identical m⁶A methyltransferase complex (m⁶A writers). Red A indicated the m⁶A modification site. B Schematic diagram presented the genomic structure of m⁶A-mRNA, unmethylated circRNAs and m⁶A-circRNAs. C c-Myc mRNA acted as a representative for m⁶A-mRNA, which was methylated at 3’-UTR and without circRNA derived. D circHIPK3 (hsa_circ_0000284) represented the group of circRNAs without m⁶A modification in neither circular transcripts nor host gene. E CircFOXM1 (hsa_circ_0025039) represented the group of circRNAs without m⁶A modification in circRNA transcript, however, their host genes were m⁶A-modified at 3’-UTR. F CircKRT5 (hsa_circ_0026457) represented the group of circRNAs only m⁶A-modified in circRNA transcript, instead of host genes. G CircIPO9 (hsa_circ_0015936) represented the group of circRNAs m⁶A-modified both in circRNA transcript and their host genes