Table 2.
Seroprevalence and Median Titers for Poliovirus Serotypes Before and After Vaccination in the 1-Drop and 2-Drop Arms
| Seroprevalence and Titers | Arm A (1-Drop mOPV2) | Arm B (2-Drop mOPV2) | P Value |
|---|---|---|---|
| Baseline seroprevalence, no./total (% [95% CI]) | |||
| Type 1 | 166/185 (89.7 [84.4–93.7]) | 170/189 (90.0 [84.8–93.8]) | >.99a |
| Type 2 | 100/185 (54.1 [46.6–61.4]) | 96/189 (50.8 [43.4–58.1]) | .54a |
| Type 3 | 153/185 (82.7 [76.5–87.9]) | 162/189 (85.7 [80.0–90.4]) | .48a |
| Baseline titer, median (IQR) | |||
| Type 1 | ≥1448 (455.1 to ≥1448) | 1152 (362 to ≥1448) | .46b |
| Type 2 | 9.0 (<8 to 22.6) | 9.0 (<8 to 28) | .98b |
| Type 3 | 910.2 (113.8 to ≥1448) | 910 (228 to ≥1448) | .45b |
| Final seroprevalence, no./total (% [95% CI]) | |||
| Type 1 | 117/130 (90.0 [83.5–94.6]) | 132/145 (91.0 [85.2–95.1]) | .84a |
| Type 2 | 105/130 (80.8 [72.9–87.2]) | 117/145 (80.7 [73.3–86.8]) | >.99a |
| Type 3 | 113/130 (86.9 [80.0–92.2]) | 124/145 (85.5 [78.7–90.8]) | .86a |
| Final titer, median (IQR) | |||
| Type 1 | ≥1448 (362 to ≥1448) | ≥1448 (910 to ≥1448) | .54b |
| Type 2 | 324 (11.3 to ≥1448) | 910 (11 to ≥1448) | .73b |
| Type 3 | ≥1448 (181 to ≥1448) | ≥1448 (455 to ≥1448) | .57b |
Abbreviations: CI, confidence interval; IQR, interquartile range; mOPV2, monovalent oral poliovirus vaccine type 2.
aFisher exact test.
bMann-Whitney U test.