Figure 1.

Schematic representation of the antigenic sites of the BP180 protein. The different epitopes of the molecule are shown. Numbers represent the first and last amino acid of each fragment/recombinat protein. The common names are listed above. The main targets are labelled with antibody reactivity (%) and IgG if not otherwise mentioned. Results in bullous pemphigoid (A), linear IgA disease, mucous membrane pemphigoid, pemphigoid gestationis, as well multiple sclerosis and Alzheimer’s disease (B) are depicetd. ECD, extracellular domain; ICD, intracellular domain; TM, transmembrane region.