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. 2022 Aug 20;15:1715–1727. doi: 10.2147/CCID.S372229

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© 2022 Wang et al.

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NO mediates the effect of luteolin on proliferation, angiogenesis and migration in HMEC-1 cells. HMEC-1 cells were transfected with Si-NC and Si-NOS3, and then treated with 10 μM luteolin. (A) The cell viability was analyzed by CCK-8 assay. (B) Tube formation experiment was used to observe the lumen structure of HMEC-1 cells. (C) migration was analyzed by scratch assays. Scale bar =200μm. The values were presented as mean ± SD (n=3). **P<0.01 and ***P<0.001 versus the Si-NC group. ^#P<0.05, ^##P<0.01 versus the luteolin + Si-NC group.