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. 2020 Oct 30;1(5):381–390. doi: 10.37349/etat.2020.00023

Figure 1.

Figure 1.

Schematic representation of PROTAC molecule acting to induce ubiquitination and subsequent proteasomal degradation of substrate POI (image adapted from [1] and modified). These small molecule degraders contain substrate-specific component, short linker, and E3-specific component