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The common types of linkers used for the design of PROTACs
| Flexible linkers (n, m = 0, 1, 2, 3, 4, etc.) | Relatively rigid linkers | Click chemistry based linkers |
|---|---|---|
alkane |
piperidine/benzene |
triazole |
alkyne-alkane |
triazole-PEG |
|
PEG |
benzene |
(CLIPTAC) |
PEG-alkane | ||
amide |
azobenzene (photoswitchable) |
