FIGURE 4.

Omics Adaptation to Altitude in Ethiopians, Tibetans, Andeans, and lowlanders who visit high-altitude environments (>3600 m). Genes with hypo- (green) and hyper- (red) methylated regions, differential transcriptomic regulation and/or up- (green) and down- (red) regulated families of proteins are listed by highland population. Metabolites and metabolic factors with increased levels and those that are activated in the corresponding population at high altitude are shown in green (red indicates downregulation).