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Use of triazoles in library synthesis. A. Azide intermediate 59 was reacted with alkynes bearing warheads for CRBN or VHL to afford two series of triazole-containing PROTACs 60 and 61 with variable linker lengths; B. amino azide intermediate 62 was conjugated to various anchors and reacted with alkyne derivatives of niraparib (63) or olaparib (64) to screen different warhead/anchor combinations. This identified potent MDM2-recruiting PROTAC 65
