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Use of co-crystal structures to identify linker conjugation sites. Arrows indicate sites on VH298 (87) that are solvent exposed. This was used to inform the design of three combinations of analogous VH032 (8) in homo-PROTACs 88-90. The morpholine nitrogen in SGK3 inhibitor 91 was shown to be solvent-exposed, and was used for linker conjugation in PROTAC 92
