Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Rational design of PROTACs from TC crystal structures. The crystal structure of MZ1 (1) suggested that the tert-butyl moiety was a better site for linker conjugation, which was used to product AT1 (93). Macrocyclisation of 1 to retain its binding conformation in the TC crystal structure afforded 94
