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. 2020 Oct 30;1(5):273–312. doi: 10.37349/etat.2020.00018

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© The Author(s) 2020.

This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Figure 2. — Structures of BRD4 degraders MZ1 (1), ARV-825 (2), and dBET1 (3). The anchors of (1) and (2–3) targeting the Von Hippel-Lindau tumour suppressor protein (VHL) and cereblon (CRBN) respectively are highlighted in blue; the common JQ1 based warhead is highlighted in green, and the linkers in black