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Early PROTAC development: the first published PROTAC degrader (4), which conjugates the angiogenesis inhibitor ovalicin to the IκBα phosphopeptide (denoted IκBα); structures of second generation PROTACs targeting the ER (5) and AR (6) receptors; the first all small-molecule PROTAC incorporating the MDM2 ligand nutlin-3 (7). In all PROTACs, the anchor is coloured blue and the warhead green
