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. 2020 Oct 30;1(5):273–312. doi: 10.37349/etat.2020.00018

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© The Author(s) 2020.

This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Figure 4. — Commonly used anchor ligands. Structure of the high-affinity ligand VH032 (8) commonly used to recruit VHL. Structures of thalidomide (9) and its analogues pomalidomide (10) and lenalidomide (11), which recruit CRBN. Methylbestatin (12) and a higher-affinity derivative of LCL161 (13) are most commonly used to target cIAP. Nutlin-3 (14) has been used to target MDM2