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Structure of the BTK covalent inhibitor ibrutinib (15) and its PROTAC counterpart P131 (16), a potent degrader of WT and C481S mutant BTK. Promiscuous kinase inhibitor foretinib (17) is incorporated into PROTAC degraders of MAPK kinases, which differ by linker composition and site of conjugation to the VHL ligand. SJFα (18) is selective for p38α and SJFδ (19) for p38δ. In all PROTACs, the anchor is coloured blue and the warhead green
