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Structures of representative PROTACs with PEG/alkyl linkers. BTK degraders (29) where the linkers are alkyl/ether chains of various combinations between 3 and 19 atoms. MDM2-targeting PROTAC with direct conjugation of the warhead to the anchor (30), although this did not function as a degrader. TBK1 PROTACs with alkyl/ether linkers between 7 and 29 atoms in length (31). In all PROTACs, the anchor is coloured blue and the warhead green
