Table 3.

Key considerations for linker motifs described

Structure	Linker type	Key points
	Alkyl/PEG	- High synthetic accessibility and commercial availability - Enable fine-tuning of linker length - Flexible
	Rigidifying groups	- Potential potency improvements - More favourable physical properties - Conformational restriction
	Clickable groups	- Facilitates library synthesis - High-yielding synthesis - Potential H-bond interactions in the TC
	CLIPTACs	- Assembled from lower MW precursors - More favourable physical properties - Compounds must be administered separately to avoid clicking
	Photoswitches	- High spatiotemporal control - May alleviate toxicity - Continuous irradiation may be required if photostates are not bistable