Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 28;61(32):e202205409. doi: 10.1002/anie.202205409

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Genome mining for putative benzoxazole biosynthetisis gene clusters. A) Sequence similarity network based on ClxD and NatAM homologs encoded in the vicinity of genes encoding enzymes putatively involved in building block activation. B) Diversity of reported and putative benzoxazole BGCs selected based on architecture diversity and/or ecological or medicinal significance of the potential producer (e.g. R. picketti is an emerging human pathogen and F. irregularis is a plant symbiont). Letters correspond to the node labels in (A). Grey genes marked as “other” also include genes encoding putative tailoring enzymes. The interested reader is directed to the respective protein identifiers in Table S7 to further explore the genome neighborhoods. The conserved subset of genes (noc) in the genome of the nocarbenzoxazole producer N. lucentensis DSM 44048 is highlighted with a dashed box. (*) not represented in sequence similarity network. AMP: adenosine monophosphate. BS: biosynthesis. NRPS: nonribosomal peptide synthetase. PKS: polyketide synthase.