Table 1.

Binding affinity values (K _{D app} ) between PABP and modified poly(A) analogs

Entry	Abbreviation	Oligonucleotide	K D app [μM]	SD [μM]
1	A12	A12	0.73	0.13
2	Aps1	A9ApsA2 D1	1.59	0.18
3	Aps2	A9ApsA2 D2	0.52	0.10
4	Aps3	A10ApsA D1	1.28	0.16
5	Aps4	A10ApsA D2	0.66	0.12
6	Aps5	ApsA11 D1	0.58	0.70
7	Aps6	ApsA11D2	1.00	0.20
8	Aps7	A5ApsA6 D1	0.70	0.13
9	Aps8	A5ApsA6D2	0.80	0.30
10	Aps9	Aps11 A	1.50	0.20
11	Aps10	ApsA9ApsA	1.22	0.13
12	A11	A11	3.10	0.60
13	A13	A13	0.66	0.12
14	G1	A11G	2.70	0.60
15	G2	A5GA6	13.00	3.00
16	G3	GA11	0.90	0.20
17	Am1	A10AmA	1.00	0.20
18	Am2	A5AmA6	4.70	0.80
19	Am3	AmA11	1.10	0.30
20	Am4	Am11A	46.0	5.0
21	Am5	AmA11Am	0.83	0.18
22	Am6	AmpsAm9AmpsAm	31.0	3.0
23	Am7	A11Am	1.50	0.40
24	m6A1	A10m6A	0.41	0.09
25	m6A2	A5m6A6	9.2	1.3
26	m6A3	m6A‐A11	0.48	0.06
27	AF1	A10AFA	0.73	0.15
28	AF2	A5AFA6	2.90	0.40
29	AF3	AFA11	1.43	0.20

K _{D app} – apparent dissociation constant value, determined via MST competition assay. SD – standard deviation of the K_D, _app values. Color‐coding: Ap_s – OAs with Ap_s modifications; A₁₁ – OAs with G substitution and different chain lengths; A_m – OAs with Am modifications; m⁶A – OAs with m⁶A modifications; A_F – OAs with A_F modifications