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. 2022 Aug 24;17(8):e0273542. doi: 10.1371/journal.pone.0273542

Fig 4. ECs with CD146 knockdown acquire a mesenchymal phenotype.

Fig 4

A HUVECs were infected with Ad–shScr and Ad–shCD146 for 48 h. The protein level of CD146 was measured by Western blot analysis. GAPDH served as an internal control. B Numbers of differentially expressed genes in comparison of HUVECs infected with Ad–shScr and Ad–shCD146. C Heatmap depicting the differentially expressed genes related to EndMT. D The mRNA levels of VWDE, ANGPT2, S100A4, ADAMTS1, SFR5, FGFR2, and Twist1 were measured by qRT–PCR analysis. *P<0.05, **P<0.01 vs. Ad–shScr. Ad–shScr: Ad–shScramble.