Fig 2. Prediction of intensive care unit (ICU) admission (A), mechanical ventilation support (B), and extracorporeal membrane oxygenation (ECMO) support (C) using serum heme oxygenase (HO)-1 (red line) and soluble CD163 (sCD163) levels (blue line).

The receiver operating characteristic (ROC) curve analyses for serum HO-1 and sCD163 levels to predict treatment outcomes including ICU admission and mechanical ventilation or ECMO support. The area under the ROC curve (AUC) for predicting ICU admission was 0.816 for serum HO-1 and 0.743 for sCD163 (A). The AUC for predicting mechanical ventilation support is 0.827 for serum HO-1 and 0.696 for sCD163 (B). The AUCs for predicting ECMO support are 0.790 and 0.598, respectively (C).