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. 2021 Dec 1;27(23):6500–6513. doi: 10.1158/1078-0432.CCR-21-1652

Figure 2.

Figure 2. Genome-wide haploid genetic screen identifies genes necessary for the activity of 3′-dA and NUC-7738. A, Flowchart of insertional mutagenesis haploid screen. B, Venn diagram illustrating the overlap of genes found in 3′-dA and NUC-7738–treated samples. C, Bubble plots of 4 independent experiments. 3′-dA and NUC-7738 treatment was performed at given concentrations. P value is given on Y axis and genes sorted by their genomic location on X axis. Bubble sizes represent the number of unique insertions that were detected.

Genome-wide haploid genetic screen identifies genes necessary for the activity of 3′-dA and NUC-7738. A, Flowchart of insertional mutagenesis haploid screen. B, Venn diagram illustrating the overlap of genes found in 3′-dA and NUC-7738–treated samples. C, Bubble plots of 4 independent experiments. 3′-dA and NUC-7738 treatment was performed at given concentrations. P value is given on Y axis and genes sorted by their genomic location on X axis. Bubble sizes represent the number of unique insertions that were detected.