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. 2021 Dec 17;12(2):331–355. doi: 10.1158/2159-8290.CD-21-1094

Figure 2.

Figure 2. A–D, Fetal adrenal gland at 21–22 weeks of gestation. A, Migrating neural crest cells penetrate through the mesodermally derived fetal adrenal cortex homing into the future adrenal medulla (H&E; original magnification 200×). B, SOX10 IHC stain highlights the nuclei of migrating neural crest cells at the periphery of the migratory clusters, representing future Schwann cell precursors (SOX10 IHC; original magnification 200×). C, Migrating neural crest cells forming a Homer Wright rosette, indistinguishable from a similar structure in a poorly differentiated neuroblastoma (see E and F). The Homer Wright rossete is shown in the center, surrounded by fetal adrenal cortex (H&E; original magnification 200×). Inset shows the nonneoplastic Homer Wright rossete at a higher magnification (400×). Note the fine cytoplasmic prolongations of the future adrenal medullary cells in the center of the rosette. D, PHOX2B IHC stain showing strong nuclear reactivity in the migrating neural crest cells of the future fetal adrenal medulla (PHOX2B IHC; original magnification 200×). E and F, Poorly differentiated neuroblastoma from a 1-year-old patient. E, Several Homer Wright rosettes are seen with their characteristic central area of neuropil (H&E; original magnification 200×). F, PHOX2B IHC stain highlighting the nuclei of the neoplastic neural crest cells (neuroblasts) in multiple Homer Wright rosettes (PHOX2B IHC; original magnification 200×).

A–D, Fetal adrenal gland at 21–22 weeks of gestation. A, Migrating neural crest cells penetrate through the mesodermally derived fetal adrenal cortex homing into the future adrenal medulla (H&E; original magnification 200×). B, SOX10 IHC stain highlights the nuclei of migrating neural crest cells at the periphery of the migratory clusters, representing future Schwann cell precursors (SOX10 IHC; original magnification 200×). C, Migrating neural crest cells forming a Homer Wright rosette, indistinguishable from a similar structure in a poorly differentiated neuroblastoma (see E and F). The Homer Wright rossete is shown in the center, surrounded by fetal adrenal cortex (H&E; original magnification 200×). Inset shows the nonneoplastic Homer Wright rossete at a higher magnification (400×). Note the fine cytoplasmic prolongations of the future adrenal medullary cells in the center of the rosette. D, PHOX2B IHC stain showing strong nuclear reactivity in the migrating neural crest cells of the future fetal adrenal medulla (PHOX2B IHC; original magnification 200×). E and F, Poorly differentiated neuroblastoma from a 1-year-old patient. E, Several Homer Wright rosettes are seen with their characteristic central area of neuropil (H&E; original magnification 200×). F, PHOX2B IHC stain highlighting the nuclei of the neoplastic neural crest cells (neuroblasts) in multiple Homer Wright rosettes (PHOX2B IHC; original magnification 200×).