Table 3.

Summary of TRAEs by dose level with every 3 weeks dosing of PF-06647020 (all cycles, N = 112).

	0.2 mg/kg n (%)	0.5 mg/kg n (%)	1.25 mg/kg n (%)	2.1 mg/kg n (%)	2.8 mg/kg n (%)	3.7 mg/kg n (%)
Evaluable pts	2	2	2	4	96	6
Number of AEs	1	1	6	28	475	27
Pts with AEs	1 (50.0)	1 (50.0)	1 (50.0)	4 (100.0)	84 (87.5)	5 (83.3)
Pts with SAEs	0	0	0	1 (25.0)	9 (9.4)	0
Pts with G3/G4 AEs	1 (50.0)	0	0	0	40 (41.7)	3 (50.0)
Pts discontinued due to AEs	0	0	0	1 (25.0)	2 (2.1)	0
Pts with dose reduction due to AEs	0	0	0	0	7 (7.3)	0
Pts with temporary discontinuation due to AEs	0	0	0	0	16 (16.7)	0
Pts with dose reduction and temporary discontinuation due to AEs	0	0	0	0	3 (3.1)	1 (16.7)

Abbreviations: AE, adverse event; Pts, patients; SAE, serious adverse event.