Table 1.

Vector‐ and mRNA‐based COVID‐19 vaccines’ ingredients and similar vaccines containing the same suspected allergen component

COVID‐19 vaccine	Active ingredient	Inactive ingredients	Storage	Incidence of anaphylactic reaction  37	Suspected allergen excipient	Other vaccine types with the same excipient	Predictive factors
Pfizer‐BioNTech	Nucleoside‐modified mRNA encoding the viral spike (S) glycoprotein of SARS‐CoV‐2	(4‐Hydroxybutyl)azanediyl)bis(hexane‐6,1‐diyl)bis(2‐hexyldecanoate)	−90 to −60°C	12.36/million	PEG 2000	N/A	previous anaphylactic reaction to drugs and vaccines; multiple allergies including drug allergies; mast cell disorders
		2[(PEG)‐2000]‐N,N‐ditetradecylacetamide
		1,2‐Distearoyl‐sn‐glycero‐3‐phosphocholine
		Cholesterol
		Salts, sugars, and buffers
Moderna	Nucleoside‐modified mRNA encoding the viral spike (S) glycoprotein of SARS‐CoV‐2	1,2‐Distearoyl‐sn‐glycero‐3‐phosphocholine	−20°C	20.39/million	PEG 2000
		PEG 2000 dimyristoyl glycerol (DMG)
		SM‐102
		Cholesterol
		Salts, sugars, and buffers
AstraZeneca	Replication‐incompetent adenovirus vector, encoding a stabilized variant of the SARS‐CoV‐2 spike (S) protein	l‐histidine	2–8°C	17.64/million	Polysorbate 80	Influenza, HPV, Hepatitis B, DTaP, Rotavirus, zoster, meningococcal group B, Japanese encephalitis
		l‐histidine hydrochloride monohydrate
		Polysorbate 80
		Salts, sugars, and buffers
Johnson & Johnson	Replication‐incompetent adenovirus vector, encoding a stabilized variant of the SARS‐CoV‐2 spike (S) protein	2‐hydroxypropyl‐β‐cyclodextrin (HBCD)	−20°C	6.53/million	Polysorbate 80
		Polysorbate 80
		Salts, sugars, and buffers

Abbreviations: N/A, not applicable; PEG, polyethylene glycol.