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. 2022 Aug 1;11:e80130. doi: 10.7554/eLife.80130

Table 2. Kinetic parameters describing force-dependent models for ternary wild type versus ternaryΔH1.

95% confidence intervals (CIs) for each parameter are obtained through empirical bootstrapping. Bound to unbound B → U single-state slip bond parameters for ternaryΔH1 correspond to the strong to unbound 2 → 0 two-state catch bond parameters for ternary wild type. Akaike information criterion (AIC) and Bayesian information criterion (BIC) indicated that the single-state slip bond model represented ternaryΔH1 data better than the two-state slip bond model.

TernaryΔH1: one-state slip bond
B → U
 kij0 0.49
CI (s−1) (0.41, 0.58)
 xij 0.48
CI (nm) (0.36, 0.60)
AIC 6.4
BIC 16.21
Ternary wild type: two-state catch bond
2 → 0 2 → 1 1 → 0 1 → 2
 kij0 0.22 6.27 13.57 0.15
CI (s−1) (0.15, 0.35) (1.61, 369.66) (13.27, 14.21) (0.05, 0.39)
 xij() 0.55 3.46 0 4.72
CI (nm) (0.28, 0.78) (1.30, 18.30) Fixed (3.92, 5.70)
 xij(+) 0.98 15 0 2.73
CI (nm) (0.74, 1.19) Fixed Fixed (2.11, 3.40)
Ternary wild type: two-state catch bond, non-directional fit
2 → 0 2 → 1 1 → 0 1 → 2
 kij0 0.19 884.52 13.28 1.17
CI (s−1) (0.05, 0.40) (5.18, 1000.0) (13.26, 14.37) (0.08, 5.39)
 xij 0.76 15.20 0 2.17
CI (nm) (0.37, 1.43) (2.44, 17.53) Fixed (1.22, 4.55)