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Flow chart of analysis strategy in genome-wide gene–sex interaction analysis in lung cancer. In genetic association analysis, all the tested SNPs have information score ≥ 0.7 in discovery data; information score > 0.2 in each of the eight studies and sample-size weighted information score ≥ 0.7 in replication data. Smoking status (ever vs. never smokers) and first five principal components were adjusted in case-only, case–control and firth validation analysis.
