Table 2.

Significant variants in gene–sex interaction analysis evaluated using Firth regression method

				Case-only								Case–control
				Discovery		Replication		Meta-analysis				Combined dataa		Score
SNP	rsID	MAF	GENE	OR	P	OR	P	P	OR	Q	I	OR	P
17:49639139:G:A	rs17662871	0.049	CA10 distal	0.69	1.21××10−7	0.80	7.03×10−2	4.29×10−8	0.71	0.27	17.10	0.78	4.06×10−3	0.72
20:15644218:T:C	rs79942605	0.012	MACROD2	2.37	9.05×10−8	1.67	6.34×10−2	2.81×10−8	2.17	0.28	14.83	1.68	1.64×10−2	0.82
21:18785818:G:A	rs208908	0.039	CXADR distal	0.71	2.84×10−6	0.67	4.49×10−3	4.54×10−8	0.70	0.76	0.00	0.80	1.74×10−2	0.85

The results from analysis using Firth logistic regression method were reported for the three variants. Infor. Q indicated P-values for Cochrane’s Q statistic; I indicated I² heterogeneity index (0–100); Score indicated the imputation quality score for the variants.

^aDiscovery and replication combined data were used for case–control validation analysis.