Table 3.

Metabolic characteristics at baseline and after 24 weeks of therapy with sac/val.

	Baseline	Follow-up	P Value
Variables	(n = 59)	(n = 59)
Fasting plasma glucose, mg/dl	109 ± 9	103 ± 8	<0.0001
Fasting plasma insulin, UI/L	16 ± 4	10 ± 4	<0.0001
HbA1C, %	6 ± 0.5	5.3 ± 0.3	<0.0001
HOMA-IR	4.4 ± 0.9	2.5 ± 0.6	<0.0001
Total cholesterol, mg/dl	194 ± 30	161 ± 28	<0.0001
HDL-cholesterol, mg/dl	50 ± 12	51 ± 10	0.6
LDL-cholesterol, mg/dl	116 ± 32	82 ± 27	<0.0001
Triglycerides, mg/dl	137 ± 58	136 ± 46	0.9
Serum UA, mg/dl	5.9 ± 0.6	4.8 ± 1.0	<0.0001

Data are means ± SD.

HbA1C, glycated hemoglobin A1C; HOMA-IR, Homeostatic Model Assessment of insulin resistance; HDL-cholesterol, high-density lipoprotein cholesterol; LDL-cholesterol, low-density lipoprotein cholesterol; serum UA, uric acid; sac/val, sacubitril/valsartan.